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Journal of Bioequivalence & Bioavailability

Raman Suresh Kumar

Raman Suresh Kumar
JSS College of Pharmacy,
Ootacamund, TamilNadu
India

Publications
  • Research Article
    Self Nanoemulsifying Drug Delivery System of Olanzapine for Enhanced Oral Bioavailability: In vitro, In vivo Characterisation and In vitro -In vivo Correlation
    Author(s): Raman Suresh Kumar, Urmila Sri Syamala, Punukollu Revathi, Punukollu Revathi, Punukollu Revathi, Sumanth Devaki, Pathuri Raghuveer and Kuppuswamy GowthamarajanRaman Suresh Kumar, Urmila Sri Syamala, Punukollu Revathi, Punukollu Revathi, Punukollu Revathi, Sumanth Devaki, Pathuri Raghuveer and Kuppuswamy Gowthamarajan

    Lipid based self nanoemulsifying drug delivery system (SNEDDS) was explored to improve the oral bioavailability of olanzapine (OLZ), a poorly water-soluble drug candidate, using spontaneous emulsification method. Nanoemulsions have ability to enhance the oral bioavailability of poorly water soluble or lipophilic drugs through selective lymphatic pathways. Following optimization, (from pseudo ternary phase diagram) OLZ SNEDDS consisting of Capryol 90(36.2%), Brij 97(14.6%) and ethanol (42.5%) were selected. The globule size (90 nm), and polydispersity index (0.287), was found to be minimum. The pharmacokinetic study was conducted on rabbits and the parameters like peak concentration (Cmax), time of peak concentration (Tmax), etc. were evaluated by Wagner nelson method. The in vivo studies concluded that there was 1.2 fold and 1.6 fold increase in bioavailability of nanoemulsion when co.. View More»
    DOI: 10.4172/jbb.1000159

    Abstract PDF