Journal of Bioequivalence & Bioavailability

Radite Nusa Senjaya

Publications

• Research Article
  Bioequivalence Study of Metformin HCl XR Caplet Formulations in Healthy Indonesian Volunteers
  Author(s): Yahdiana Harahap, Santi Purnasari, Hayun, Krisnasari Dianpratami, Mahi Wulandari, Rina Rahmawati, Fadlina Chany and Radite Nusa SenjayaYahdiana Harahap, Santi Purnasari, Hayun, Krisnasari Dianpratami, Mahi Wulandari, Rina Rahmawati, Fadlina Chany and Radite Nusa Senjaya
  
  Aim: Determination of the bioequivalence of two metformin HCl (750 mg) caplet formulations (Glucophage XR® from Bristol-Myres Squibb Company, Indonesia as a reference formulation and Glumin XR® from Ferron Par Pharmaceutical, Indonesia as a test formulation). Material and method: The study was conducted according to an open label, randomized, Two-period crossover design with a 1 week washout period. Twelve volunteers participated and all completed the study successfully. Blood samples were obtained prior to dosing and at 1.0; 1.5; 2.0; 2.5; 3.0; 3.5; 4.0; 6.0; 8.0; 10.0; 14.0; 18.0; 24.0 and 30.0 hours after drug administration. Plasma will be separated by centrifuge and stored frozen at -20 degree Celcius. Plasma concentration of metformin HCl was monitored using high performance liquid chromatography (HPLC) with photo diode array (PDA) detection over a period of 30 hours a.. View More»
  DOI: 10.4172/jbb.1000051

  Abstract PDF