Journal of Bioequivalence & Bioavailability

Rabia Ismail Yousuf

Publications

• Research Article
  Pharmacokinetic and Bioequivalence Studies of Oral Cefuroxime Axetil 250 mg Tablets in Healthy Human Subjects
  Author(s): Iyad Naeem Muhammad, Muhammad Harris Shoaib, Rabia Ismail Yousuf and Rabia Ismail YousufIyad Naeem Muhammad, Muhammad Harris Shoaib, Rabia Ismail Yousuf and Rabia Ismail Yousuf
  
  The objective of this study was to determine the bioequivalence of two Cefuroxime oral 250 mg tablet formulation. One was the innovators brand (Zinnat®), was taken as reference brand (REF) and the other was a newly developed, optimized and cost effective formulation (TEST). A single dose, open, random sequence, cross over, two treatment study with a one week washout period in between was carried out in 12 healthy male Pakistani young volunteers. Reference and Test tablets were administered to these volunteers with 150 mL of water after an overnight fast. Blood samples were drawn 15 min prior to the administration of dose and at 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7 and 8 hours post dose. The cefuroxime concentrations in the plasma were determined by a modified, simple HPLC method in which the mobile phase was 10 mM solution of ammonium acetate and acetonitrile, pH was adjusted to 5 &plusm.. View More»
  DOI: 10.4172/jbb.10000196

  Abstract PDF