Journal of Nanomedicine & Nanotechnology

R. Lee Mosley

Publications

• Research Article
  Active Targeted Macrophage-mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease
  Author(s): Yuling Zhao, Matthew J. Haney, Vivek Mahajan, Benjamin C. Reiner, Anna Dunaevsky, R. Lee Mosley, Alexander V. Kabanov, Howard E. Gendelman and Elena V. BatrakovaYuling Zhao, Matthew J. Haney, Vivek Mahajan, Benjamin C. Reiner, Anna Dunaevsky, R. Lee Mosley, Alexander V. Kabanov, Howard E. Gendelman and Elena V. Batrakova
  
  We previously demonstrated that monocyte-macrophage based drug delivery can be applied to a spectrum of infectious, neoplastic, and degenerative disorders. In particular, bone marrow-derived macrophages (BMM) loaded with nano formulated catalase, “ nanozyme”, were shown to attenuate neuro inflammation and nigrostriatal degeneration in rodent models of Parkinson’s disease (PD). Nonetheless, the pharmacokinetics and biodistribution of BMM- incorporated nanozyme has not been explored. To this end, we now demonstrate that BMM, serving as a “depot” for nanozyme, increased area under the curve(AUC), half-life, and mean residence time in blood circulation of the protein when compared to the nanozyme administered alone. Accordingly, bioavailability of the nanozyme for the brain, spleen, kidney,.. View More»
  DOI: 10.4172/2157-7439.S4-003

  Abstract PDF