Dentistry

Qin Man

Publications

• Research Article
  Mutation Survey of the PHEX Gene and Oral Manifestation in a Chinese Family with X-linked Dominant Hypophosphatemic Ricket
  Author(s): Wang Yuanyuan,Chen Jie,Wu Nan,Zhao Yuming,Ge Lihong,Qin Man* Wang Yuanyuan,Chen Jie,Wu Nan,Zhao Yuming,Ge Lihong,Qin Man*
  
  Objective: X-linked dominant hypophosphatemic rickets is the most common genetic disorder of renal phosphate wasting with an approximate prevalence of 1 in 20,000 in humans. Until now, no more than 15 mutations in the PHEX gene have been reported in Chinese patients with familial XLH among the all the 338 PHEX mutations. The aim of this study is describe the oral manifestation of a Chinese XLH family, analyze the dentin structure alteration and gene mutation. Methods: In this XLH family, the oral manifestation was described by panoramic tomograph and oral photographs, dentin structure alteration was studied by both tooth section and 3D morphology measurement laser microscope, the gene mutation was studied by PCR technique. Results: Pulp infection and teeth loss were facilitated in XLH patients due to the anatomy change, .. View More»
  DOI: 10.4172/2161-1122.1000402

  Abstract PDF