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Puguh Riyanto
Puguh Riyanto
Indonesia
Publications
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Research Article
Soy Isoflavones Reduce Toll-like Receptor-2 Levels in Acne Vulgaris
Author(s): Puguh Riyanto and Rosa LelyanaPuguh Riyanto and Rosa Lelyana
Background: Acne vulgaris (AV) is one of the most common skin inflammatory diseases. The results studies proved that soy isoflavones have anti-androgenic and anti-inflammatory. The objective of this study was to analyze the effect of soy isoflavone in AV lesions in women with AV. Method: Randomized pre- and post-test control design, with 40 women, randomized into 2 groups: placebo and treatment. This study has done for 12 weeks. Soy isoflavones regarded as independent variable. AV lesions regarded as dependent variable and TLR-2 as intervening variable. Results: The study found a reduction in total AV lesions after treatment, from 80.0 ± 5.27 to 78.8 ± 27.46 in the placebo group and from 83.8 ± 37.82 to 34.0 ± 24.82 in the treatment group, with a significant mean difference (p<0.05). TLR-2 level has increased from 4505.5 ± 3084.0 pg/ml to 6005.6 &.. View More»
DOI: 10.4172/2157-7439.1000430