Journal of Thrombosis and Circulation: Open Access

Priyadarshini B

Publications

• Review Article
  Hemophagocytic Lymphohistiocytosis - Case History and Review of Literature
  Author(s): Sasidharan PK and Priyadarshini BSasidharan PK and Priyadarshini B
  
  Hemophagocytic lymphohistiocytosis or HLH is a very rare underdiagnosed potentially fatal entity which frequently leads to multiorgan failure and death due to immune dysregulation. It can be either primary which is supposed to be an inherited disorder seen in infancy and childhood or secondary to infections, connective tissue disorders or malignancies which is seen in all ages. The disease manifestation is due to massive release of inflammatory cytokines (cytokine storm) into the circulation which is out of control of the immune system. The cytokines activate the macrophages which lead to phagocytosis of the hemopoietic cells including precursors leading to cytopenias. Clinically it is mistaken for bone marrow infiltrating diseases like leukemia, lymphoma, and several other entities. It is important to have a high index of suspicion for diagnosis since an early diagnosis is crucial to.. View More»
  DOI: 10.4172/2572-9462.1000107

  Abstract PDF