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Prasannavadhana
Prasannavadhana
India
Publications
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Review Article
Emergence of Carbapenemase Producing Pathogens in Animals
Author(s): Monika Bhardwaj, Bhoj R Singh, M Senthil Murugan, Prasannavadhana and Sakshi DubeyMonika Bhardwaj, Bhoj R Singh, M Senthil Murugan, Prasannavadhana and Sakshi Dubey
Carbapenems are beta (β)-lactam antibiotics active against wide range of bacteria. Carbapenem resistance may be outcome of efflux pump activation, alteration in protein binding proteins, production of carbapenemases which degrade carbapenems. There are number of bacteria producing different types of carbapenemases like NDM (Enterobacteriaceae), IMP (Pseudomonas aeruginosa), IMI (Enterobacter cloacae), KPC (Klebsiella pneumonia), OXA-23, OXA-24/40, OXA-58-type (Acinetobacter baumannii), VIM (Acinetobacter baumannii) etc. Carbapenem resistance is emerging throughout the world due to interspecies transfer of genetic elements carrying genes for carbapenemase production. It is very difficult to control spread of resistant strains because of the continuous threshold of selection present in forms of presence of carbapenems in environment created through wide spread clinical use. To cont.. View More»
DOI: 10.4172/2153-2435.1000379