Prabhat Upadhyay
India
Research Article
Effect of a Novel Polyherbal Formulation on Diabetes Induced Memory Deficits in Rats
Author(s): Prabhat Upadhyay,Ananya Sadhu*,Suresh Purohit,Praveen K Singh,Shivapriya Shivakumar ,Aruna Agrawal,K. Ilango,Govind Prasad Dubey
Prabhat Upadhyay,Ananya Sadhu*,Suresh Purohit,Praveen K Singh,Shivapriya Shivakumar ,Aruna Agrawal,K. Ilango,Govind Prasad Dubey
Abstract
Epidemiological, clinical and experimental studies have shown a strong correlation between Diabetes mellitus (DM) and neurodegenerative disorders. Type II diabetes mellitus (T2DM) leads to elevated levels of plasma glucose and causes neurological complications including impairment of learning and memory processes. The pathogenesis mainly includes metabolic dysfunction due to brain insulin resistance, oxidative stress, inflammation and vascular complications. In this study we explored a new pharmacological intervention by investigating the neuroprotective effects of a standardized polyherbal formulation (PF) [(Bacopa monnieri (20 mg/kg), Hippophae rhamnoides (25 mg/kg), and Dioscorea bulbifera (15 mg/kg), p.o] on passive avoidance learning (PAL) and memory in normal and streptozotocin (STZ) induced diabetic rats. Treatment was started after the onset of hyperglycemia following .. View More»
DOI:
10.4172/2161-1459.1000194