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Ponizovskiy MR
Ponizovskiy MR
Head of Laboratory Biochemistry and Toxicology, Kiev Regional p/n Hospital,
Kiev
Ukraine
Publications
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Review Article
Mechanism of Changes Balance Anaerobic Processes and Aerobic Processes in Cancer Metabolism Causing Warburg Effect Mechanism
Author(s): Ponizovskiy MRPonizovskiy MR
Changes balance catabolic anaerobic exergonic processes of oxidative phosphorylation and catabolic aerobic exergonic processes of respiratory oxidation induce violation interaction between mitochondrial oxidative processes and nuclear proliferative function. Just the changes balance catabolic anaerobic processes and catabolic aerobic processes cause transition Pasteur Effect “incompatible glycolysis and aerobic oxidation” in norm into Warburg effect “aerobic glycolysis” of cancer metabolism. Normal Stationary State of balance anabolic endergonic processes and catabolic exergonic processes is mutated into Quasi-stationary pathologic State due to the shift balance anabolic processes and catabolic processes into excessive anabolic processes with partial suppression catabolic processes in cancer tissue. Considering Krebs tricarboxylic citric acids cycle as the link.. View More»
DOI: 10.4172/2167-7956.1000150