Cardiovascular Pharmacology: Open Access

Pollen K. Yeung

Publications

• Research Article
  A Study of the Effect of Isoproterenol on Red Blood Cell Concentrations of Adenine Nucleotides in a Freely Moving Rat Model In Vivo*
  Author(s): Pollen K. Yeung and Dena Seto Pollen K. Yeung and Dena Seto
  
  Previous studies have shown that red blood cell (RBC) concentrations of adenine 5’-triphosphate (ATP) may be a key factor for post-exercise effects responsible for cardiovascular protection. To test this concept further, we investigated the effect of isoproterenol on ATP metabolism in RBC using a freely moving rat model in vivo. Sprague Dawley rats were given either isoproterenol (30 mg/kg) or saline by subcutaneous (sc) injection. Blood samples were collected sequentially for up to 6 hours for measurement of adenine nucleotides in the RBC. Hemodynamic recordings were collected throughout the experiment. We have found isoproterenol induced 50% mortality under the experimental condition. It decreased systolic blood pressure (SBP) and diastolic blood pressure (DBP) immediately after the injection by -64 ± 22 and -64 ± 20 mmHg in less than 15 min, and increased HR ste.. View More»
  DOI: 10.4172/2329-6607.1000102

  Abstract PDF