Journal of Bioequivalence & Bioavailability

Piyapat Pongnarin

Publications

• Research Article
  Bioequivalence Study of 1,500 mg Glucosamine Sulfate in Thai Healthy Volunteers
  Author(s): Pravit Akarasereenont, Somruedee Chatsiricharoenkul and Piyapat PongnarinPravit Akarasereenont, Somruedee Chatsiricharoenkul and Piyapat Pongnarin
  
  Glucosamine sulfate is widely used to relieve symptoms from osteoarthritis. This study was conducted in order to determine pharmacokinetic and assessed the in-vivo bioequivalence of two different hard capsule formulations of glucosamine sulfate when administered as equal dose of 1,500 mg. The two formulations contain different salt form where reference product is NaCl and test product is KCl. A randomized, single dose, two-treatment, two- period, two-sequence crossover study was conducted. Twenty-six healthy volunteers were recruited at Siriraj Clinical Research Unit. Each subject received a dose of 1,500 mg glucosamine sulfate of both formulations with at least a week washout period. Blood samples were collected over 24 hrs after the oral administration. The plasma fractions were analyzed for glucosamine using LC-MS/MS. Twenty-six volunteers enrolled in the present study. Pharmacokin.. View More»
  DOI: 10.4172/jbb.10000119

  Abstract PDF