Journal of Stem Cell Research & Therapy

Pinhal NS

Publications

• Research Article
  Convulsive Seizure Protection after Hippocampal Transplantation of Mesenchymal Cells from Adipose Tissue in Mice
  Author(s): Tamura BP, Almeida DC, Felizardo RJ, Olanda GC, Bocca LF, Pinhal NS, Alves-de-Moraes LBC, Covolan L, Câmara NOS and Longo BMTamura BP, Almeida DC, Felizardo RJ, Olanda GC, Bocca LF, Pinhal NS, Alves-de-Moraes LBC, Covolan L, Câmara NOS and Longo BM
  
  A considerable number of epileptic patients had become resistant to antiepileptic drugs, justifying the need for development of new therapeutic strategies to treat epilepsy. The use of mesenchymal stem cells is an innovative and accessible strategy for the treatment of neuronal disorders, due to their involvement in immunoregulatory mechanisms, trophic and anti-apoptotic action. Objective: Based on this evidence, we evaluated the protective effect of mesenchymal cells from adipose tissue (MCAT) by behavioral and inflammatory responses against convulsive seizure induced by maximum electroconvulsive shock (MES). Methods: MCAT cells were transplanted into the hippocampus of adult male mice, and ten days after the transplantation MES stimulation was applied to induce a generalized tonic-clonic seizure. To evaluate the anticonvulsant activity of MCAT cells, we evaluated the parameters invo.. View More»
  DOI: 10.4172/2157-7633.1000196

  Abstract PDF