Journal of Bioequivalence & Bioavailability

Pia Nunes

Publications

• Research Article
  Single and Multiple Pharmacokinetics of Enrofloxacin and Ciprofloxacin in Pigs
  Author(s): Claudio Araneda, Paulina Villar, Carolina Cuadros, Mauricio del Valle, Pia Nunes and Margarita SantelicesClaudio Araneda, Paulina Villar, Carolina Cuadros, Mauricio del Valle, Pia Nunes and Margarita Santelices
  
  Pharmacokinetics of Enrofloxacin (ENR) and Ciprofloxacin (CPX) in pig plasma was studied by HPLC-FL analysis using two injectable solutions, Enromic ® 20% (single dose of 7.5 mg ENR Kg -1 body weight) and Enromic ® 10% (multiple dose of 2.5 mg ENR Kg -1 body weight/day during 3 consecutive days). For the method validation, standard calibration curves were prepared between 0.025 and 0.5 μg mL -1 , with r 2 >0.9998 for both analytes. Quantification limits were 0.0282 and 0.0289 μg mL -1 for ENR y CPX, respectively; recovery percentages vary between 90.09% and 104.84% for ENR, and 63.01% and 89.01% for CPX, and precision obtained for measurements made on different days, expressed as %RSD, varied between 2.70% and 15.26% for ENR, and between 6.58% and 13.31% for CPX. Pharmacokinetic parameters gave values for Enromic ® 20% of 1.139 ± 0.320 μg mL -1 (C max ),.. View More»
  DOI: 10.4172/jbb.1000132

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