Advances in Pharmacoepidemiology and Drug Safety

Pedro A López-Saura

Publications

• Research Article
  Medical Practice Confirms Clinical Trial Results of the Use of Intralesional Human Recombinant Epidermal Growth Factor in Advanced Diabetic Foot Ulcers
  Author(s): Pedro A López-Saura, Isis B Yera-Alos, Carmen Valenzuela-Silva, Odalys González-Díaz, Amaurys del Río-Martín, Jorge Berlanga-Acosta, José I Fernández-Montequín, Boris Acevedo-Castro, Ernesto López-Mola and Luis Herrera-MartínezPedro A López-Saura, Isis B Yera-Alos, Carmen Valenzuela-Silva, Odalys González-Díaz, Amaurys del Río-Martín, Jorge Berlanga-Acosta, José I Fernández-Montequín, Boris Acevedo-Castro, Ernesto López-Mola and Luis Herrera-Martínez
  
  The intralesional injection of recombinant human epidermal growth factor (rhEGF) has been recently approved and introduced in several countries for the treatment of advanced diabetic foot ulcers (DFU), based on the results of five exploratory and one confirmatory, phase III clinical trials in 344 subjects. A significant stimulatory effect of this product on the healing process, given by development of granulation tissue and re-epithelization was shown in these trials, as well as a reduction in lesion recurrences during follow-up, and a tendency to a reduction of the risk of amputations, with an acceptable safety profile. However, products not always perform the same way in current medical practice. The present review summarizes the clinical information available from the intralesional use of rhEGF for advanced DFU and shows that in this case the postmarket.. View More»
  DOI: 10.4172/2167-1052.1000128

  Abstract PDF