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Pawan Gupta
Pawan Gupta
India
Publications
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Research Article
Improved Extraction of Intracellular Biogenic Selenium Nanoparticles and their Specificity for Cancer Chemoprevention
Author(s): Praveen Sonkusre, Ravikanth Nanduri, Pawan Gupta and Swaranjit Singh CameotraPraveen Sonkusre, Ravikanth Nanduri, Pawan Gupta and Swaranjit Singh Cameotra
Selenium is reported to have excellent anticancer activity at higher doses. However, due to its low therapeutic index, it is desirable to have a selenium form with lesser toxicity even at high therapeutic dose; alternatively it would be progressive to attempt efficacious preparation at very low concentration. In this study, selenium nanoparticles were synthesized biologically by Bacillus licheniformis JS2, and a method was developed for extraction and purification of intracellular nanoparticles. Characterization of extracted nanoparticles for shape, size, and purity indicated that the particles were spherical with diameters ranging between 40 and 180 nm, composed of selenium and capped with a few functional groups that probably provide steric stability to them. These neutral charged, non-agglomerating selenium nanoparticles at a concentration as low as 2 μg Se/mL were effi.. View More»
DOI: 10.4172/2157-7439.1000194