Tropical Medicine & Surgery

Paula M Frew

Publications

• Research Article
  Enrollment in YFV Vaccine Trial: An Evaluation of Recruitment Outcomes Associated with a Randomized Controlled Double-Blind Trial of a Live Attenuated Yellow Fever Vaccine
  Author(s): Paula M Frew, Eve T Shapiro, Lu Lu, Srilatha Edupuganti, Harry L Keyserling and Mark J MulliganPaula M Frew, Eve T Shapiro, Lu Lu, Srilatha Edupuganti, Harry L Keyserling and Mark J Mulligan
  
  This investigation evaluated several factors associated with diverse participant enrollment of a clinical trial assessing safety, immunogenicity, and comparative viremia associated with administration of 17-D live, attenuated yellow fever vaccine given alone or in combination with human immune globulin. We obtained baseline participant information (e.g., sociodemographic, medical) and followed recruitment outcomes from 2005 to 2007. Of 355 potential Yellow Fever vaccine study participants, 231 cases were analyzed. Strong interest in study participation was observed among racial and ethnically diverse persons with 36.34% eligible following initial study screening, resulting in 18.75% enrollment. The percentage of white participants increased from 63.66% (prescreened sample) to 81.25% (enrollment group). The regression model was significant with white race as a predictor of enrollment (.. View More»
  DOI: 10.4172/2329-9088.1000117

  Abstract PDF