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Paula G Burkard
Paula G Burkard
Tanzania
Publications
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Case Report
Seroquel Induced Liver Injury
Author(s): Muhammad Tahir* and Paula G Burkard Muhammad Tahir* and Paula G Burkard
The drug induced liver injury by antipsychotics is a well reported subject in the medical literature. The hepatotoxic effects have been reported by atypical antipsychotic drugs like clozapine, risperidone and olanzapine [1]. The Quetiapine induced hepatocellular damage is relatively a rare incident. It is an atypical antipsychotic agent proven to be effective for the management of negative and positive symptoms of the psychosis [2]. It is a dibenzothiazepine derivative which works by mediating through a combined antagonism of dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors. Although considering its wide therapeutic range up to 750mg/day, it has a low side effect profile [3]. The common side effects reported are asymptomatic liver enzymes elevation, pancytopenia and thrombotic thrombocytopenic purpura [4]. The rare side effects reported are Neuroleptic malignant syndromes [.. View More»
DOI: 10.4172/2167-0889.1000222