Journal of Bioequivalence & Bioavailability

Paul A. Nakata

Publications

• Research Article
  Genetically Modified Medicago truncatula Lacking Calcium Oxalate has Increased Calcium Bioavailability and Partially Rescues Vitamin D Receptor Knockout Mice Phenotypes
  Author(s): Xiangkai Li, Jian Yang, Jay Morris, Ashley Hester, Paul A. Nakata and Kendal D. HirschiXiangkai Li, Jian Yang, Jay Morris, Ashley Hester, Paul A. Nakata and Kendal D. Hirschi
  
  Background: How the distribution and sequestered form of plant macro/micro-nutrients influence their bioavailability, and ultimately impact human health, are poorly understood. The legume Medicago truncatula has a portion of its tissue calcium (Ca) sequestered in the form of the Ca oxalate (CaOx) crystal which reduces its nutritional value in terms of Ca bioavailability. The calcium oxalate deficient 5 (cod5) mutant has a total Ca content similar to wild-type (WT) plants, but sequesters less of its tissue Ca in the form of the CaOx crystal. Previous short-term mice feeding studies suggest that this difference is responsible for the improved Ca bioavailability of the cod5 plants compared to WT plants. Objectives: To perform long term feeding studies with Vitamin D Receptor Knockout (VDR-KO) mice and the nutritionally improved cod5 line to assess the .. View More»
  DOI: 10.4172/jbb.1000133

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