Journal of Stem Cell Research & Therapy

Palayakotai R Raghavan

Publications

• Research Article
  Metadichol^® and CD33 expression in Umbilical Cord Cells
  Author(s): Palayakotai R Raghavan Palayakotai R Raghavan
  
  CD33 also known as Siglec-3 is endogenously expressed in stem cells and is a marker for the myeloid lineage of cells. Increased expression of CD33 thus allows it to bind to any Sialic Acids (SIAs). These acids are binding sites for pathogens and toxins. By binding to these acids, CD33 can prevent invasion of hosts by these pathogens. Down-regulation of CD33, increase the release of the pro-inflammatory cytokine TNF-α by monocytes that increases reactive oxygen species that are involved in diseases like diabetes mellitus, Alzheimer’s, cardiovascular diseases asthma, and in various cancers. The up-regulation of CD33 using Metadichol® was studied using Wharton’s Jelly Mesenchymal Stem Cells (MSCs) isolated from human umbilical cord were used which were grown in p-35 dishes until confluent and treatment was carried out with different concentratio.. View More»
  DOI: 10.4172/2157-7633.1000443

  Abstract PDF