Biology and Medicine

Palaniappan Maheswari

Publications

• Research Article
  Evaluation of Angiogenic Potential of 1-Monocaproin Using Chick Chorioallantoic Membrane Assay
  Author(s): Palaniappan Maheswari and Kasthuri RevathiPalaniappan Maheswari and Kasthuri Revathi
  
  1-Monocaproin, a 1-monoacylglycerol, was synthesized with the reaction of glycidol by chromium-caproic fatty acid complexes and was found to be amphiphilic in nature. Synthesized 1-monocaproin was characterized by thin-layer chromatography, and the residual chromium was analyzed using inductively coupled plasma mass spectroscopy. Vascular endothelium growth factor (VEGF)-mediated angiogenesis pathways are being targeted for the development of novel drugs suitable for inhibition or stimulation of angiogenesis in various pathologies. In the chicken egg Chorioallantoic membrane (CAM) assay, 1-monocaproin exhibited VEGF-induced neovascularization in a dose-dependent manner. Synthesized 1-monocaproin was found to show the angiogenic effect at a dose concentration equivalent to VEGF at 1,000 ppm. The results thus suggest that 1-monocaproin should be considered as a useful drug candidature t.. View More»
  DOI: 10.4172/0974-8369.1000401

  Abstract PDF