Oluwamolakun O Bankole
Nigeria
Research Article
Inhibition of Dopamine Receptor in Neonate Hippocampus: Immunolocalization of Post Synaptic Density Protein-95 and Dopamine Receptor in vivo
Author(s): Babafemi J Laoye, Oluwamolakun O Bankole, Esther A Ekundayo and Azeez O IsholaBabafemi J Laoye, Oluwamolakun O Bankole, Esther A Ekundayo and Azeez O Ishola
The effect of haloperidol on neonatal dopaminergic neurotransmission in the hippocampus of postnatal day 20
rats (P.20) was investigated in this study. Haloperidol blocked dopamine receptors (D2R) and inhibited D2R on the
membrane of neonate neurons. For this study the 0.5 ml (20 mg/kg) of haloperidol was administered to pregnant
female animals intraperitoneally a week before delivery. At day P.20, 5 control animals and 5 haloperidol treated
animals were taken to the behavioral studies room for the Y maze and Novel object recognition test, which was done
7 am in the morning before mating. Electrophysiology was done with 2 control pups and 2 treated pups. Electrodes
were implanted in the brain at the hippocampal region 2 mm beneath the bregma, 2 mm lateral to the midline.
Anterior Posterior (AP=0), Medial Lateral (ML=2 mm). Also immunolocalization and immunofluorescence of post
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DOI:
10.4172/0974-8369.1000441