Pharmaceutica Analytica Acta

Olowosulu AK

Publications

• Research Article
  Comparative FTIR, Compaction and In vitro Dissolution Studies of Plectranthus esculentus Modified Starches in Metronidazole Tablet Formulations by Direct Compression
  Author(s): Khalid GM, Musa H, Olowosulu AK, Jatau AI, Ilyasu S and Gwarzo MS Khalid GM, Musa H, Olowosulu AK, Jatau AI, Ilyasu S and Gwarzo MS
  
  Wet and dry granulation methods for tablet manufacturing tend to be problematic for thermolabile and moisture sensitive drugs, and few excipients are available for use in direct compression (DC) due to stringent requirements. This study aimed to evaluate the drug/excipients compatibility, compaction and in vitro dissolution properties of Plectranthus esculentus modified starches in tablets using metronidazole as a model drug by DC. Native starch extracted from P. esculentus was modified by three methods and we produced three modified starches namely; acid hydrolyzed P. esculentus starch (APS), pregelatinized P. esculentus starch (PPS), and ethanol dehydrated pregelatinized P. esculentus starch (PPE). For drug/excipient compatibility studies, Fourier Transform Infrared Spectroscopy (FTIR) was used. Powder compaction was evaluated using Heckel model, while in vitro dissolution studies were.. View More»
  DOI: 10.4172/2153-2435.1000577

  Abstract PDF