Journal of Nanomedicine & Nanotechnology

Nur Izyani Kamaruzman

Publications

• Research Article
  Nanoparticle-facilitated Intratumoral Delivery of Bcl-2/IGF-1R siRNAs and p53 Gene Synergistically Inhibits Tumor Growth in Immunocompetent Mice
  Author(s): Anil Philip Kunnath, Nur Izyani Kamaruzman and Ezharul Hoque Chowdhury Anil Philip Kunnath, Nur Izyani Kamaruzman and Ezharul Hoque Chowdhury
  
  Breast cancer, the leading cause of cancer-related deaths in women, is usually treated with surgery, radiation therapy, hormone-blocking/chemotherapy drugs, monoclonal antibodies or combinations of these approaches and agents depending on the cancer stage and the existence of specific receptors, with accompanying various adverse effects. Silencing of the genes responsible for cancer development and progression with small interfering RNA (siRNA) in combination with overexpression of the genes with tumor suppressing activities could be an attractive concept for precisely treating breast cancer with minimal side effects. However the short half-life in plasma due to nuclease-mediated degradation and renal clearance, and the inefficiency in penetrating the plasma membrane limit the applications of siRNA and DNA as therapeutic molecules. Recently, we have developed pH-sensi.. View More»
  DOI: 10.4172/2157-7439.1000278

  Abstract PDF