Journal of Nanomedicine & Nanotechnology

Norazlinaliza Salim

Publications

• Research Article
  Phase Behaviour, Formation and Characterization of Palm-Based Esters Nanoemulsion Formulation containing Ibuprofen
  Author(s): Norazlinaliza Salim, Mahiran Basri, Mohd. Basyaruddin Abd. Rahman, Dzulkefly Kuang Abdullah, Hamidon Basri and Abu Bakar SallehNorazlinaliza Salim, Mahiran Basri, Mohd. Basyaruddin Abd. Rahman, Dzulkefly Kuang Abdullah, Hamidon Basri and Abu Bakar Salleh
  
  Palm-based esters, synthesized through enzymatic transesterification of palm oil fractions with oleyl alcohol have potential application in pharmaceutical formulations. The phase behaviour of palm-based esters containing ibuprofen with surfactant of different HLB values was investigated for topical delivery system. The surfactants were Tween 85, Tween 60 and Tween 80, and the palm-based esters were palm oil esters (POEs) and palm kernel oil esters (PKOEs). Ternary phase diagrams of palm-based esters: Ibuprofen/surfactant/water systems were constructed. Three distinct regions were observed in the phase diagrams; isotropic liquid region, L 1 , liquid crystalline region, L c and multiphase region, M. Nanoemulsions were prepared spontaneously by the addition of water to oil:ibuprofen/surfactant mixtures based on the ternary phase diagrams constructed. Fo.. View More»
  DOI: 10.4172/2157-7439.1000113

  Abstract PDF