Advances in Pharmacoepidemiology and Drug Safety

Ning Zhang

Publications

• Research Article
  Epidemiological Study of AGT Gene Polymorphism among Chinese Subjects with Primary Hypertension
  Author(s): Ning Zhang, Lili Yang, Huadong Cui and Wenyi Fu Ning Zhang, Lili Yang, Huadong Cui and Wenyi Fu
  
  Background: Polymorphisms in the promoter region of the angiotensinogen (AGT) gene may affect AGT transcription and thus blood pressure. We determined the frequency of the AGT A-20C polymorphism in Chinese patients with primary hypertension. Using a molecular epidemiology approach, we also determined the relationship between primary hypertension and environmental-AGT A-20C polymorphism interactions. Methods: 912 subjects diagnosed with primary hypertension were analyzed from Shenyang Chinese Populationsand their samples were genotyped using A-20C polymorphism within angiotensinogen (AGT) gene by ô€€µestriction ô€€©ragment ô€€¯ength Polymorphism methods (PCR-RFLP) Results: PCR and restriction fragment length polymorphism techniques were used to determine the distribution frequen.. View More»
  DOI: 10.4172/2167-1052.1000110

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