Journal of Bioequivalence & Bioavailability

Nimmathota Madhavi

Publications

• Research Article
  Formulation and Evaluation of Phenytoin Sodium Sustained Release Matrix Tablet
  Author(s): Nimmathota Madhavi, Beeravelli Sudhakar, P.V.Ravikanth, Kodisana Mohon and Kolapalli Ramana MurthyNimmathota Madhavi, Beeravelli Sudhakar, P.V.Ravikanth, Kodisana Mohon and Kolapalli Ramana Murthy
  
  Epilepsy is a very common disorder, characterized by seizures, which take various forms and result from episodic neuronal discharges, the form of the seizure depending on the part of the brain affected. There is no recognition cause, although it may develop after brain damage, such as trauma, infection or trauma, and other kinds of neurological diseases. Epilepsy is treated mainly with drugs, though brain surgery may be used for severe cases. Sodium channel blockers are generally used in the treatment of seizures, e.g.: phenytoin, carbamazepine, sodium valproate. The aim of this study is to develop sustained release matrix tablet of phenytoin sodium using eudragit- RL100, eudragit-RS100, HPMC-E15, ethyl cellulose (N-14), Chitosan and HPMC as release controlling factor and to evaluate drug release parameters as per various release kinetic models. The formulated tablets were also charac.. View More»
  DOI: 10.4172/jbb.1000125

  Abstract PDF