Journal of Stem Cell Research & Therapy

Nicoletta Orlando

Publications

• Short Communication
  Graft Composition and Post-Thawing Cell Viability Influence the Hematopoietic Recovery in Autologous Hematopoietic Stem Cell Transplantation
  Author(s): Caterina Giovanna Valentini, Maria Bianchi, Nicoletta Orlando, Francesco Autore, Maria Grazia Iachininoto, Nicola Piccirillo, Simona Sica, Gina Zini, Valerio De Stefano and Luciana Teofili Caterina Giovanna Valentini, Maria Bianchi, Nicoletta Orlando, Francesco Autore, Maria Grazia Iachininoto, Nicola Piccirillo, Simona Sica, Gina Zini, Valerio De Stefano and Luciana Teofili
  
  Objective: We investigated the influence of graft composition and post-thawing cell viability on the hematopoietic recovery of patients undergoing Autologous Hematopoietic Stem Cell Transplantation (ASCT). Methods: Data relative to 146 ASCT procedures performed in 134 patients were examined. The doses of CD34+ cells and parameters related to the grafts’ composition (white blood cell – WBC, neutrophil and platelet -PLT concentrations) were correlated to the number of days for neutrophil and platelet engraftment. Moreover, patients were grouped according to the values of post-thawing total nucleated cell (TNC) and CD34+ cell viability (as lower of higher than median values of the entire series) and hematopoietic recovery was accordingly evaluated. Results: The CD34+ cell dose significantly predicts both neutrop.. View More»
  DOI: 10.4172/2157-7633.1000379

  Abstract PDF