Journal of Thrombosis and Circulation: Open Access

Nicolas Lembert

Publications

• Research Article
  Efficacy of A Collagen Hemostat Versus A Carrier-bound Fibrin Sealant
  Author(s): Erich K Odermatt, Heiko Steuer and Nicolas Lembert Erich K Odermatt, Heiko Steuer and Nicolas Lembert
  
  Aim: A fast activation time of hemostatic agents with blood must be sufficient to effectively stop bleeding within surgical procedures. However, there are no functional in-vitro tests of hemostatic agents which mimick such a clinical application. Method: The efficacy of two common hemostatic agents was examined with heparinised human whole blood (0.7 IU/ml) and a contact time of only three minutes between blood and hemostatic agents. Traditional biochemical assays were compared with a new rheometric method for measuring clot formation. Results: Blood without previous material contact (negative control) induced a basal thrombin-antithrombin (TAT, 240 ± 85 μg/l) or ß-thromboglobulin (TG, 1000 ± 216 U/ml) complex formation. Stainless steel (positive control) or a thrombin coated equine collagen fleece failed to increase TAT or ß-TG. However, a bovine collagen.. View More»
  DOI: 10.4172/2572-9462-3-120

  Abstract PDF