Pharmaceutica Analytica Acta

Ngeranwa JJN

Publications

• Research Article
  Blood Glucose Lowering Effect and Safety of the Aqueous Leaf Extracts of Zanha africana
  Author(s): Abdirahman YA, Juma KK, Makori WA, Agyirifo DS, Ngugi MP, Gathumbi PK, Ngeranwa JJN and Njagi ENMAbdirahman YA, Juma KK, Makori WA, Agyirifo DS, Ngugi MP, Gathumbi PK, Ngeranwa JJN and Njagi ENM
  
  Zanha africana has been used traditionally to manage many diseases including diabetes, however, its antidiabetic activity and safety is not well evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of the aqueous leaf extracts of this plant in male Swiss white albino mice. The antidiabetic activity was screened in alloxan induced diabetic mice using oral and intraperitoneal routes. The safety of the extract was studied in mice that were orally and intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording changes in body and organ weights, hematological and biochemical parameters. Mineral composition was estimated using total reflection X-ray fluorescence system and atomic absorption spectrometry. Phytochemical composition was assessed using standard procedures. The extract showed hypoglycemic activity at dose levels of .. View More»
  DOI: 10.4172/2153-2435.1000422

  Abstract PDF