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Neha Sylvia Walter
Neha Sylvia Walter
India
Publications
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Research Article
Antimalarial Efficacy of Thalictrum foliolosum (Meadow rue) Against Chloroquine-Resistant P. falciparum
Author(s): Neha Sylvia Walter and Upma Bagai Neha Sylvia Walter and Upma Bagai
Background: Investigation of traditionally used medicinal plants can provide safe and cost effective good antimalarials. The present study explores the in vitro antimalarial potential of Thalictrum foliolosum (meadow rue) leaf extract against Plasmodium falciparum. Methods: Phytochemical screening of the extract was carried out following standardized methods. WHO method based on schizont maturation inhibition was employed to assess the in vitro antiplasmodial activity of plant extract. Colorimetric MTT assay was used to evaluate the in vitro cytotoxicity of Thalictrum foliolosum. Selectivity Index was also calculated. Results: Phytochemical screening of the extract revealed presence of alkaloids, phenols, triterpenes, saponins and phytosterols. Ethanolic leaf extract of Thalictrum foliolosum (ELETF) exhibited IC50<5 μg/ml against chloroquine (CQ) resistant (RKL-9) strains of P.. View More»
DOI: 10.4172/2329-891X.1000163