Journal of Nanomedicine & Nanotechnology

Natalia Lemos Chaves

Publications

• Research Article
  Rhodium Citrate Associated with Maghemite Nanoparticles Causes DNA Fragmentation Independently of Caspases 3 and Mediated by Reactive Oxygen Species
  Author(s): Natalia Lemos Chaves, Cláudio Afonso Pinho Lopes, Marcella Lemos Brettas Carneiro, Aparecido Ribeiro de Souza, Matheus Oliveira da Silva, José Raimundo Corrêa and Sônia Nair Báo Natalia Lemos Chaves, Cláudio Afonso Pinho Lopes, Marcella Lemos Brettas Carneiro, Aparecido Ribeiro de Souza, Matheus Oliveira da Silva, José Raimundo Corrêa and Sônia Nair Báo
  
  Breast cancer is the most common cancer among women, excluding non-melanoma skin cancer. Research efforts have been directed towards the development of more efficient drugs against this disease, such as metal complexes, which have been widely studied. These compounds can intercalate in DNA bases and impair DNA transcription and replication, leading to cell death. Cell death can also be associated with early induction of reactive oxygen species (ROS) production by cells treated with this kind of metal complex. Nevertheless, the use of these compounds is limited because of their systemic toxicity. In this regard, the use was proposed of dirhodium citrate [Rh2(H2cit)4] associated with magnetic nanoparticles (NPs), which are carriers that may work in decreasing systemic toxicity. We compared cell viability effects of free Rh2(H2cit)4, Rh2.. View More»
  DOI: 10.4172/2157-7439.1000312

  Abstract PDF