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Nasr AA
Nasr AA
International Centre for Bioavailability, Pharmaceutical and Clinical Research,
Obour City
Egypt
Publications
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Research Article
A Rapid and Sensitive UPLC-MS/MS Method for the Determination of Adefovir in Human Plasma: Application to a Pharmacokinetic Study
Author(s): Nasr AA, Abo-Aly MM, Makram TS and Alzoubi MI Nasr AA, Abo-Aly MM, Makram TS and Alzoubi MI
A sensitive, rapid and selective liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) analytical method based on protein precipitation was developed and validated for analysis of Adefovir in human plasma. Adefovir-d4 was used as an internal standard and Waters X-Select HSS T3-C18 (3.0 × 50 mm, 2.5 μm) column provided the desired chromatographic separation of compounds followed by detection with mass spectrometry. The method used simple isocratic chromatographic condition and mass spectrometric detection in the positive ionization mode. The calibration curves were linear over the range of 1.00 ng/mL to 30.00 ng/mL with the lower limit of quantitation validated at 1.00 ng/mL. The degree of matrix effect for Adefovir was determined in six different sources of human plasma was 5.23% and had no impact on study samples analysis with the shortest runtime obtained (1.5 min). .. View More»
DOI: 10.4172/jbb.1000358