Journal of Nanomedicine & Nanotechnology

Naoki Nakajima

Publications

• Research Article
  In Vivo Cancer Targeting of Water-Soluble Taxol by Folic Acid Immobilization
  Author(s): Junichi Nakamura, Naoki Nakajima, Kazuaki Matsumura and Suong-Hyu HyonJunichi Nakamura, Naoki Nakajima, Kazuaki Matsumura and Suong-Hyu Hyon
  
  Previously, folic acid receptor-targeted Dextran-Taxol-Folic acid (Dex-TXL-FA) has shown the in vitro superior and selective antitumor activity against human oral cancer cell line (KB) compared with the absent of folic acid, Dextran- Taxol. Present study is given for further investigation of in vivo antitumor efficacy of Dex-TXL-FA in the murine tumor xenograft model. To evaluate the antitumor effect of taxol, tumor bearing mice were prepared by s.c. inoculation of 1.0 × 10 6 KB cells in the back of nude mice. Seven days after inoculation, the administration of saline, paclitaxel for injection (PTX), Dex-TXL, FA-adsorbed Dex-TXL and Dex-TXL-FA (covalent) was started at a dose of 10mg/kg, by i.v. injection via the lateral tail vein three times ( on day 7, 9, and 11) and animal survival rate and tumor sizes were monitored.FA- adsorbed Dex-TXL and Dex-TXL-FA (covalent) sh.. View More»
  DOI: 10.4172/2157-7439.1000106

  Abstract PDF