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Nand Kishore
Nand Kishore
Chemistry, Indian Institute of Technology-Bombay,
Powai, Mumbai
India
Publications
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Review Article
Biological Wonders of Osmolytes: The Need to Know More
Author(s): Eva Judy and Nand Kishore Eva Judy and Nand Kishore
Nature has selected osmolytes to protect intracellular macromolecules against denaturing stress conditions. These molecules are accumulated in the intracellular environment at considerably high concentrations. In general, osmolytes are known to stabilize proteins. However, under certain conditions, their destabilizing properties have also been pointed out. A careful qualitative and quantitative understanding of the mechanism of action of osmolytes with proteins from native to different stages of aggregation/fibrillation is extremely important in rational drug design. This review highlights the importance of naturally occurring osmolytes in protein folding, stabilization, and prevention of fibrillation/aggregation related diseases among others. Continued efforts are required to get quantitative insights into osmolyte-protein interactions along with experimental evidences for the much c.. View More»
DOI: 10.4172/2161-1009.1000304