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Namita Giri
Namita Giri
Tanzania
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Research Article
Advanced Mucus Infiltrating Nanoparticles for Microbicide Delivery
Author(s): Namita Giri and Chi H LeeNamita Giri and Chi H Lee
Advanced mucus infiltrating nanoparticles (NPs) based on ES-100 have been developed for the intravaginal delivery of Dapivirine against HIV-1. They were further surface engineered with poly ethylene glycol (PEG) that helps them overcome the mucosal barrier via enhanced pH-mediated infiltration properties. PEG coated NPs (PCN) loaded with Dapivirine was characterized for particle size distribution, morphology, loading efficiency and mucus infiltration properties. The cellular uptake profiles of PCN by human vaginal epithelial cells (VK2 E6/E7) were examined using confocal microscopy. The cytotoxicity of PCN was assessed using MTS assay as well as Annexin V-FITC/PI assays. The mucus infiltration rates of PCN were examined on the in-vitro simulated cervico-vaginal mucus system and ex vivo porcine vaginal tissues. PCN loaded with Dapivirine possessed physiochemical properties, readily tra.. View More»
DOI: 10.4172/2157-7439.1000479