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Nag K
Nag K
Japan
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Research Article
PKC Activation Promotes Internalization of DNA-Immobilized Inorganic Nano-Crystals by Clathrin-Dependent Endocytosis for Efficient Transgene Expression in Human Lymphocytes
Author(s): Nag K, Hossain S, Sultana N and Chowdhury EHNag K, Hossain S, Sultana N and Chowdhury EH
Leukemia and lymphoma cells are potential targets in cancer therapy for genetic manipulation either by transgene expression or silencing of endogenous gene expression. In addition, genetically engineered autologous lymphocytes expressing a chimeric antigen against a receptor overexpressed in tumor or tumor vasculature are promising cellbased therapeutics for cancer. The major hurdle to the successful implementation of these attractive approaches is the lack of a smart device for efficient transgene delivery and expression in the lymphocytes. Recently, we developed an efficient nanocarrier of carbonate apatite for intracellular delivery and release of DNA molecules, achieving very high level of transgene expression in primary as well as cancer cell lines. However, its efficacy in human T leukemia cells is comparatively low. Here, we reveal that simultaneous stimulation of human T leuke.. View More»
DOI: 10.4172/2157-7439.1000174