Cardiovascular Pharmacology: Open Access

Myrmel T

Publications

• Short Communication
  Adrenomedullin Stimulates Porcine Sinus Node Automaticity
  Author(s): Stenberg TA, Koren S, Kildal AB and Myrmel T* Stenberg TA, Koren S, Kildal AB and Myrmel T*
  
  Adrenomedullin (AM) is a vasodilatory and chronotropic peptide that has cardioprotective properties in settings of ischemia-reperfusion. Specifically, the 52-amino acid peptide hormone has been shown to reduce infarct size and potentially be protective against malignant arrhythmias. AM reduces L-type calcium currents in rabbit ventricular myocytes, and can possibly be utilized as an antiarrhythmic drug. However, at present it is unclear whether AM has cardiac electrophysiological effects in vivo. In the present study, we investigated whether AM affects sinus and atrioventricular nodal functions, cardiac pacing thresholds, refractory properties and intracardiac conduction intervals in an intact porcine model (Norwegian landrace and Yorkshire hybrids; n=12). Hemodynamic and electrophysiological parameters were recorded at baseline and following 60 min of AM-infusion (.. View More»
  DOI: 10.4172/2329-6607.1000215

  Abstract PDF