Journal of Blood Disorders & Transfusion

Muneaki Ohshita

Publications

• Research Article
  25% Albumin Infusion Maintains Antithrombin III (AT) Activity after AT Agent Administration in Critically Ill Patients with Disseminated Intravascular Coagulation (DIC)
  Author(s): Mayuki Aibiki, Noriyasu Fukuoka, Shiro Bando, Hironori Matsumoto, Muneaki Ohshita, Souichi Maekawam and Jun Takebe Mayuki Aibiki, Noriyasu Fukuoka, Shiro Bando, Hironori Matsumoto, Muneaki Ohshita, Souichi Maekawam and Jun Takebe
  
  Objective: To report for the first time critically ill patients with disseminated intravascular coagulation (DIC) in whom the infusion of 25% albumin solution produces remarkable elevations in plasma antithrombin III (AT) activities after administration of AT agents. Design: A prospective observational study. Interventions: 1) Plasma AT activities were serially measured in DIC patients after AT administration, enable us to analyze their pharmacokinetics; 2) Comparisons of AT activities between two groups of receiving AT agent with or without the infusion of 25% albumin solution; 3) in vitro examinations were conducted to define whether albumin application itself would influence directly an AT measurement system using samples already determined the levels of AT activities. Methods and main results: Twenty consecutive critical patien.. View More»
  DOI: 10.4172/2155-9864.1000208

  Abstract PDF