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Mumtaz V Rojiani
Mumtaz V Rojiani
Departments of Pathology and Medicine, Medical College of Georgia, Georgia Regents University,
Augusta GA 30912
Tanzania
Publications
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Review Article
Matrix Metalloproteinases-Modulating the Tumor Microenvironment
Author(s): Marzenna Wiranowska, Amyn M Rojiani and Mumtaz V Rojiani Marzenna Wiranowska, Amyn M Rojiani and Mumtaz V Rojiani
Observations on the collagenolytic activity of endopeptidases in tadpoles undergoing metamorphosis were the early steps in defining this family of matrix metalloproteinases (MMP). Extensive investigations into these enzymes in plants and animals have revealed the highly pleiotropic nature of these molecules, both in physiologic and pathologic conditions. The human MMP family is comprised of over 23 members, which are capable of degrading and processing almost all components of the extracellular matrix (ECM) such as proteins and proteoglycans including those of basement membrane. MMPs also can cleave a wide variety of non-matrix substrates such as cytokines, chemokines, growth factors and their receptors as well as adhesion. Molecules important in tumor microenvironment and at all stages of tumor progression. .. View More»
DOI: 10.4172/2157-2518.1000225