Bioenergetics: Open Access

Mukul Das

Publications

• Research Article
  Argemone Oil and Butter Yellow Induced Toxicity in Hepatic and Extra Hepatic Tissues
  Author(s): Vivek Mishra, Manjari Mishra, Bhushan P Chaudhari, Raj Khanna and Mukul Das Vivek Mishra, Manjari Mishra, Bhushan P Chaudhari, Raj Khanna and Mukul Das
  
  Objective: The present study was designed to evaluate the toxicological potential of argemone oil (AO) and butter yellow (BY). Methods: Short term treatment through intraperitoneal administration in hepatic tissue and long term treatment through diet in hepatic and extra hepatic tissues was performed in mice. Results: Short term study showed that female mice were more prone towards risk associated with liver damage than the males. Further investigations in female mice given AO (1%) and BY (0.06%) through diet for 180 days, showed significant weight loss and increase in liver weight. Phase I and Phase II enzymes, antioxidant enzymes and glutathione content were significantly decreased with concomitant increase in lipid peroxidation (LPO) in AO and BY treated mice. Animal fed with AO and BY showed profuse hyperplasia.. View More»
  DOI: 10.4172/2167-7662.1000111

  Abstract PDF