Journal of Bioequivalence & Bioavailability

Mudassar Hassain

Publications

• Research Article
  Analgesic Action by Neuroleptics in Diabetic State
  Author(s): Sadia Suri Kashif, Sadaf Naeem, Nausheen A Sarosh and Maqsood Ahmed Khan Sadia Suri Kashif, Sadaf Naeem, Nausheen A Sarosh and Maqsood Ahmed Khan
  
  Purpose: To assess the analgesic role of neuroleptics in hyperglycemic state. Methods: Amytryptiline and carbamazepine were selected for study. This study was carried out at Pharmacology lab, Institute of Research Pharmaceutical sciences, University of Karachi, and comprised of male and female mice, half of which were made diabetic by giving Alloxan. The objective of this study is to monitor the effects of neuroactive agents on analgesic activity in hyperglycemic mice. Results: It was observed that Amytryptiline exhibited highly significant analgesic effect in normal as compared to diabetic subjects. It was also observed that both amytryptiline and carbamazepine produce more rapid onset of action and longer duration of action in normal animals when compared with diabetic animals. Conclusion: The p.. View More»
  DOI: 10.4172/0975-0851.1000373

  Abstract PDF