Journal of Liver

Motohiro Shimizu

Publications

• Research Article
  Efficacy and Tolerance of Interferon β Plus Ribavirin Treatment for Chronic Hepatitis C Patients with Depression or Thrombocytopenia Comparison with Pegylated Interferon α Plus Ribavirin Treatment
  Author(s): Hiroaki Ikezaki, Norihiro Furusyo, Eiichi Ogawa, Motohiro Shimizu, Satoshi Hiramine, Kazuya Ura, Fujiko Mitsumoto, Kouji Takayama, Kazuhiro Toyoda, Masayuki Murata and Jun Hayashi Hiroaki Ikezaki, Norihiro Furusyo, Eiichi Ogawa, Motohiro Shimizu, Satoshi Hiramine, Kazuya Ura, Fujiko Mitsumoto, Kouji Takayama, Kazuhiro Toyoda, Masayuki Murata and Jun Hayashi
  
  Objective: Limited data has been reported comparing natural human interferon β (nIFNβ) and pegylated IFN-α (PEG-IFNα) when Ribavirin (RBV) is combined. This case-control study was done to compare the efficacy and adverse effects of a combination treatment of nIFNβ or PEG-IFNα plus RBV for chronic hepatitis C patients. Methods: Sixty patients with chronic hepatitis C, 42 infected with hepatitis C virus (HCV) genotype 1 and 18 infected with genotype 2, were treated with nIFNβ plus RBV. Of them, 23 (38.3%) suffered pre-treatment severe depression. Their data was compared with 60 undepressed patients treated with a combination of PEG-IFNα plus RBV. nIFNβ was given intravenously and PEG-IFNα was injected subcutaneously. Results: Sustained virological response (undet.. View More»
  DOI: 10.4172/2167-0889.1000155

  Abstract PDF