Journal of Nanomedicine & Nanotechnology

Moraima Morales-Cruz

Publications

• Research Article
  Induction of Cancer Cell Death by Hyaluronic Acid-Mediated Uptake of Cytochrome C
  Author(s): Cindy M Figueroa, Moraima Morales-Cruz, Bethzaida N Suárez, Jean C Fernández, Anna M Molina, Carmen M Quiñones and Kai Griebenow Cindy M Figueroa, Moraima Morales-Cruz, Bethzaida N Suárez, Jean C Fernández, Anna M Molina, Carmen M Quiñones and Kai Griebenow
  
  Effective cancer treatment needs both, passive and active targeting approaches, to achieve highly specific drug delivery to the target cells while avoiding cytotoxicity to normal cells. Protein drugs are useful in this context because they can display excellent specificity and potency. However, their use in therapeutic formulations is limited due to their physical and chemical instability during storage and administration. Polysaccharides have been used to stabilize proteins during formulation and delivery. To accomplish both, stabilization and targeting simultaneously, the apoptosis-inducing protein cytochrome c (Cyt c) was modified with the polysaccharide hyaluronic acid (HA) because its corresponding receptor CD44 is overexpressed in many cancers. Cyt c-HA bioconjugates were formed using low and high molecular weight HA (8 kDa and .. View More»
  DOI: 10.4172/2157-7439.1000316

  Abstract PDF