Journal of Bioequivalence & Bioavailability

Monica Kothari

Publications

• Research Article
  Bioavailability and Interaction Potential of Atorvastatin and Losartan on Co-administration in Healthy Human Subjects
  Author(s): Tausif Ahmed, Sivacharan Kollipara, Anirudh Gautam, Radhika Gigras, Monica Kothari, Nilanjan Saha, Vijay Batra and Jyoti PaliwalTausif Ahmed, Sivacharan Kollipara, Anirudh Gautam, Radhika Gigras, Monica Kothari, Nilanjan Saha, Vijay Batra and Jyoti Paliwal
  
  A randomized, open-label, balanced, three-treatment, three-sequence, three-period single dose crossover pharma- cokinetic interaction study was conducted to evaluate the potential of interaction between Atorvastatin (AT) and Losartan (LS). Subjects were administered either 40 mg AT or 100 mg LS or combination of both in either of the periods. Blood samples were collected at regular intervals to measure the plasma concentrations of AT, O-hydroxy atorvastatin (O-HAT), LS and its carboxylic acid metabolite (LS-CA) for pharmacokinetic analysis. Co-administration of AT and LS was well tolerated without any significant change in area under the curve (AUC) of either of the drugs or their respective metabolites. There was an increase in C max (ng/mL) of AT, O-HAT, LS, and LS-CA by 29% (38.8(±20.9) to 47.8(±18.4)), 86% (15.7±(10.6) to 29.8(±19.1)), 51% (503.0(±246.0) t.. View More»
  DOI: 10.4172/jbb.1000004

  Abstract PDF