Pharmaceutica Analytica Acta

Mohammad Sarwar

Publications

• Research Article
  Determination of Organic Volatile Impurities in Twenty-Three Different Coated Tablet Formulations Using Headspace Gas Chromatography with Flame Ionization Detection Technique
  Author(s): Abida Latif, Humera Shafi Makhdoom, Muhammad Imran, Mohammad Mazhar, Emman Anwar, Mohammad Sarwar and Muhammad Ashraf Tahir Abida Latif, Humera Shafi Makhdoom, Muhammad Imran, Mohammad Mazhar, Emman Anwar, Mohammad Sarwar and Muhammad Ashraf Tahir
  
  Organic solvents are extensively used in manufacturing processes of pharmaceutical formulations that cannot be completely eliminated from the product due to physical and chemical barriers. These solvents have no therapeutic value and may be toxic to human body if intake exceeds the permitted daily exposure. Therefore, a simple and sensitive method for simultaneous determination of methanol, acetonitrile, methylene chloride, n-hexane, cyclohexane, xylene, chloroform, nitromethane, toluene and pyridine was developed and validated. Separation was achieved on HP-Innowax polyethylene glycol gas chromatographic column (30 m × 250 μm × 0.25 μm) using Agilent 7890B gas chromatograph equipped with Agilent 7697A headspace auto-sampler and flame ionization detector. Twenty-three marketed coated tablet formulations (containing diclofenac sodium, Loratadine or montelukast sodium .. View More»
  DOI: 10.4172/2153-2435.1000553

  Abstract PDF