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Mohammad E Khosroshahi
Mohammad E Khosroshahi
Center for Advanced Diffusion-Wave Technologies (CADIFT),
M5S 3G8
Canada
Publications
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Research Article
In-vitro Application of Doxorubicin Loaded Magnetoplasmonic Thermosensitive Liposomes for Laser Hyperthermia and Chemotherapy of Breast Cancer
Author(s): Mohammad E Khosroshahi, Lida Ghazanfari, Zahra Hassannejad and Steven Lenhert Mohammad E Khosroshahi, Lida Ghazanfari, Zahra Hassannejad and Steven Lenhert
We describe doxorubicin loaded magnetoplasmonic thermosensitive liposomes (MPTL-DOX), which are designed to combine features of magnetic drug targeting and laser hyperthermia-triggered drug release. The synthesized magnetite/gold nanoshells are stabilized using polyvinyl pyrolidone (PVP) with mean crystallite size of 15.8 ± 3.5 nm. The liposome formulation DPPC:cholesterol:DSPE-PEG2000 at 80:20:5 molar ratio shows DOX release of less than 5% at 37°C following 24 h incubation. MPTL-DOX shows encapsulation efficiencies of about 95% and 74% for DOX and magnetoplasmonic nanoshells (MPNS), respectively. The MPTL-DOX formulation displays a desired temperature sensitivity with 65% and 100% DOX release following laser irradiation and then 24 h incubation at 37°C, respectively. The rate of DOX release from liposome using this formulation is 0.09 which was obtain.. View More»
DOI: 10.4172/2157-7439.1000298