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Mohammad A Khiyami
Mohammad A Khiyami
Saudi Arabia
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Research Article
Liposomal β-Glucan: Preparation, Characterization and Anticancer Activities
Author(s): Majed Halwani, Zakir Hossain, Mohammad A Khiyami and Abdelwahab Omri Majed Halwani, Zakir Hossain, Mohammad A Khiyami and Abdelwahab Omri
Context: An assortment of 1,3-β-glucans have been explored for their structural and pharmacological capabilities. The immunomodulatory effects of 1,3-β-glucans have served to fight cancer. Objectives: The aim of this work was the investigation of the physiocochemical characterizations of 1,3-β-D-glucan encapsulation of liposomes and their effects on human lung carcinoma epithelial cell line A549. aterials and Methods: β-glucan was encapsulated into liposomes composed of different lipids and cholesterol [PC, PC:Chol (6:1), DDAB:DPPC:Chol (4:2:1), DCP:DPPC:Chol (4:2:1), DPPC:Chol (6:1), DSPC:Chol (6:1), DSPC]. The liposomal formulations were prepared by the hydration-dehydration method. The mean diameter of liposomes and the polydispersity index were determined by photon correlation spectroscopy (PCS) with the use.. View More»
DOI: 10.4172/2157-7439.1000319