Journal of Allergy & Therapy

Mohamed Zedan

Publications

• Research Article
  Single Nucleotide Polymorphism of IL4C-590T and IL4RA 175V and Immunological Parameters in Egyptian Asthmatics with Different Clinical Phenotypes
  Author(s): Magdy Zedan, Ashraf Bakr, Basma Shouman, Hosam Zaghloul, Mohammad Al-Haggar, Mohamed Zedan and Amal Osman Magdy Zedan, Ashraf Bakr, Basma Shouman, Hosam Zaghloul, Mohammad Al-Haggar, Mohamed Zedan and Amal Osman
  
  Objectives: Circulating cytokines and genetic patterns may help to discriminate certain asthma phenotypes. Methods: Eighty two uncontrolled asthmatic children and twenty controls were enrolled in the study. After validation of asthma symptoms, three proposed phenotypes were formed: cough, Shortness Of Breath (SOB), and cough with SOB. Measurement of pulmonary function tests, Fractional Exhaled Nitric Oxide (FENO), eosinophilic percentage, serum levels of total IgE, IL-17 and IL-9 were done. Two Single-Nucleotide Polymorphisms (SNPs) in IL4 and IL4RA were genotyped using PCR-RFLP method. Results: Regarding SNP IL4RA-175V, cases showed heterozygous AG predominance whereas controls showed more homozygous GG genotype. Cough group showed significant decrease in both FEV1/FVC ratio in comparison to SOB and cough with SOB groups. Also, this group showed strong inverse rel.. View More»
  DOI: 10.4172/2155-6121.1000189

  Abstract PDF