Journal of Nanomedicine & Nanotechnology

Mohamed H. Khedr

Publications

• Research Article
  Mesoporous Silica Materials in Drug Delivery System: pH/Glutathione- Responsive Release of Poorly Water-Soluble Pro-drug Quercetin from Two and Three-dimensional Pore-Structure Nanoparticles
  Author(s): Khaled E.A. AbouAitah, Ahmed A. Farghali, Anna Swiderska-Sroda, Witold Lojkowski, AbdelFattah M. Razin and Mohamed H. Khedr Khaled E.A. AbouAitah, Ahmed A. Farghali, Anna Swiderska-Sroda, Witold Lojkowski, AbdelFattah M. Razin and Mohamed H. Khedr
  
  Quercetin (Quer) is one of natural products (pro-drugs), presenting pharmacological properties such as: anti-oxidant, anti-inflammatory and anti-cancer activities. However, poor solubility of the Quer causes its poor bioavailability, and consequently reduces its therapeutic efficiency. To manage this problem, different actions are undertaken, among other drug delivery systems (DDSs) are investigated. The objective of present work was to evaluate potential applications of silica nanoparticles as quercetin nanocarriers and to investigate the influence of pH conditions and glutathione (GSH, as non-redox process) concentrations on quercetin release. Two types of mesoporous silica nanoparticles: MCM-41 (2D arrangement of pores) and KCC-1 (3D arrangement of pores) were synthesized and then functionalized by amino-groups. Immersion-evaporation method was use.. View More»
  DOI: 10.4172/2157-7439.1000360

  Abstract PDF